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Valium (Diazepam) is a popular benzodiazepine used to treat anxiety and muscle spasms. The article explains its dissimilarities with other benzos and tells about Valium interactions with other medicines.

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How Is Valium Different from Other Benzos? How Valium Interacts with Other Medicines?

Valium is a widely used preparation, which is effective against a range of medical conditions, including acute alcohol withdrawal, anxiety, restless leg syndrome, insomnia, and many more. This drug belongs to the family of benzodiazepines, which includes many other preparations with pronounced anxiolytic, muscle relaxing, and sedative effects.

The similarity of the effects of Valium and other benzos makes it difficult to understand why you should choose Valium and not the other benzodiazepine drug. Let’s try to figure this out by comparing Valium with some most popular benzodiazepines.

Valium vs. Ativan

The potency of these medications is their primary dissimilarity. A 10 mg dosage of Diazepam (the active substance in Valium) equals 2 – 2.5 mg of Lorazepam, which is the active substance in Ativan. This seems to give more points to Ativan, but, based on the results of clinical studies, Valium is better absorbed from the gastric tract, which means that it comes into effect faster than Ativan. So if you need to quickly cut off the edge of the upcoming panic attack, Valium is preferable.

The half-life of Valium is 50 hours. It’s a long-acting benzodiazepine. Ativan, in its turn, is a short-acting agent, which is excreted from the organism within 10 – 20 hours only. However, the clinical effects of Valium are shorter than those of Ativan.

Valium vs. Xanax

Both Valium (Diazepam) and Xanax (Alprazolam) are well-known for their effectiveness. Both representatives of this family of medicines are short-acting medications. Their primary difference, aside from the active substances, lies in their indications.

Valium is recommended in people suffering from seizure disorders, muscular spasticity, and other health conditions, while Xanax is officially allowed for anxiety disorders, predominantly generalized anxiety, and panic attacks. Therefore, these medications are not interchangeable, especially if you administer Valium for seizures.

The onset of action of Valium is typically faster than that of Xanax. Besides, Valium works longer compared to Xanax.

Another thing that differs Valium from Xanax is the price. Valium is much more affordable than Xanax, which often becomes a decisive factor for people who hesitate about the choice of the drug.

Valium vs. Klonopin

Valium and Klonopin have a lot in common. They are intended to help treat seizures, yet only Valium is effective against alcohol withdrawal and muscle spasms. Valium is recommended by the FDA for anxiety, while Klonopin is not. Vice versa, Klonopin is allowed for panic disorder, while Valium is prescribed for this purpose off-label.

Choosing Klonopin, you will require lower dosages of the medication. However, Clonazepam the active component in Klonopin, needs more time to come into effect than Valium. The latter works within 15 – 60 minutes, while Klonopin needs 1 – 4 hours to reach peak plasma concentrations.

There’s no better or worse medication here. These benzodiazepines are just different, though their mechanism of action and effects produced are similar. To decide which one is best for you, consult your healthcare provider. And remember, whichever drug you choose, it won’t be 100% safe.

Drugs to Avoid When on Valium (Diazepam)

Valium produces pronounced effects on the nervous system, depressing it. Keeping that in mind, it’s crucial to avoid taking other medicines with similar effects. Why is it so important? The thing is that the interaction of Valium (Diazepam) with other CNS depressants may lead to life-threatening side effects as these medicines create a synergistic effect when used concomitantly.

Diazepam potentiates the effects of alcohol, barbiturates, antidepressants, muscle relaxants, and some other medications. For instance, the intake of Valium together with Ambien (zolpidem) increases the risks for side effects, particularly drowsiness, trouble concentrating, dizziness, and confusion.

By no means should you combine Valium with opioid analgesics. Their concomitant use multiplies the risks of breathing insufficiency and respiratory depression. Potentially, this may lead to coma and death. Tell your doctor that you take oxycodone, tramadol, or any other opioid medication before getting a prescription for Valium.

If you use oral birth control pills, you may need your Valium dose adjustment. Oral contraceptives decrease the elimination of diazepam metabolites from the body, leading to excessive sedation.

Summing up

Although Valium, Xanax, Ativan, and Klonopin belong to the same class of drugs and similarly interact with other medications, they are all different and are not interchangeable. But if you think you will benefit more from the other benzodiazepine, talk about that with your healthcare provider.